Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9^-/- mice to colitis.

ABSTRACT:

Background

The etiology of inflammatory bowel disease (IBD) is unclear but involves both genetics and environmental factors, including the gut microbiota. Indeed, exacerbated activation of the gastrointestinal immune system toward the gut microbiota occurs in genetically susceptible hosts and under the influence of the environment. For instance, a majority of IBD susceptibility loci lie within genes involved in immune responses, such as caspase recruitment domain member 9 (Card9). However, the relative impacts of genotype versus microbiota on colitis susceptibility in the context of CARD9 deficiency remain unknown.

Results

Card9 gene directly contributes to recovery from dextran sodium sulfate (DSS)-induced colitis by inducing the colonic expression of the cytokine IL-22 and

SUBMITTER: Danne C 

PROVIDER: S-EPMC11036619 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature