<i>Anaerostipes hadrus</i>, a butyrate-producing bacterium capable of metabolizing 5-fluorouracil.

ABSTRACT: Anaerostipes hadrus (A. hadrus) is a dominant species in the human gut microbiota and considered a beneficial bacterium for producing probiotic butyrate. However, recent studies have suggested that A. hadrus may negatively affect the host through synthesizing fatty acid and metabolizing the anticancer drug 5-fluorouracil, indicating that the impact of A. hadrus is complex and unclear. Therefore, comprehensive genomic studies on A. hadrus need to be performed. We integrated 527 high-quality public A. hadrus genomes and five distinct metagenomic cohorts. We analyzed these data using the approaches of comparative genomics, metagenomics, and protein structure prediction. We also performed validations with culture-based in vitro assays. We constr

SUBMITTER: Liu D 

PROVIDER: S-EPMC11036815 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature