Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury.

ABSTRACT: Preconditioning with lipopolysaccharide (LPS) induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways. Microglia are resident immune cells of the central nervous system (CNS) that respond early to danger signals through memory-like differential reprogramming. However, the cell-specific molecular mechanisms underlying preconditioning are not fully understood. To elucidate the distinct molecular mechanisms of preconditioning on microglia, we compared these cell-specific proteomic profiles in response to LPS preconditioning and without preconditioning and subsequent transient focal brain ischemia and reperfusion, - using an established mouse model of transient focal brain ischemia and reperfusion. A proteomic workflow, based on isolated mic

SUBMITTER: Helbing DL 

PROVIDER: S-EPMC11036884 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature