SMART use of medications for the treatment of adolescent severe obesity: A sequential multiple assignment randomized trial protocol.

ABSTRACT:

Background

Severe obesity is a complex, chronic disease affecting nearly 9% of adolescents in the U.S. Although the current mainstay of treatment is lifestyle therapy, pediatric clinical practice guidelines recommend the addition of adjunct anti-obesity medication (AOM), such as phentermine and topiramate. However, guidance regarding when adjunct AOM should be started and how AOM should be used is unclear. Furthermore, an inherent limitation of current treatment guidelines is their "one-size-fits-all" approach, which does not account for the heterogeneous nature of obesity and high degree of patient variability in response to all interventions.

Methods

This paper describes the study design and methods of a sequential multiple assignment randomized trial (SMART), "SMART Use o

SUBMITTER: Fox CK 

PROVIDER: S-EPMC11037878 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature