Plasma proteomic profile of abdominal obesity in older adults.

ABSTRACT:

Objective

This study examines the plasma proteomic profile of abdominal obesity in older adults.

Methods

The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was examined in 969 Ashkenazi Jewish participants (LonGenity cohort), aged 65 years and older (mean [SD] age 75.7 [6.7] years, 55.4% women), using regression models. Pathway analysis, as well as weighted correlation network analysis, was performed. WC was determined from the proteome using elastic net regression.

Results

A total of 480 out of 4265 proteins were associated with WC in the linear regression model. Leptin (β [SE] = 12.363 [0.490]), inhibin β C chain (INHBC; β [SE] = 24.324 [1.448]), insulin-like growth factor-binding protein 2 (

SUBMITTER: Sathyan S 

PROVIDER: S-EPMC11039368 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature