Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration.

ABSTRACT: Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances yet. Current knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic damage. But to date, the absence of promising therapeutic biomaterials/scaffolds remains. The reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of scaffolds. To address these issues, in this study, we systematically investigated the cellular fate determinations and t

SUBMITTER: Wu J 

PROVIDER: S-EPMC11039626 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature