POLE -related gene signature predicts prognosis, immune feature, and drug therapy in human endometrioid carcinoma.

ABSTRACT: The POLE subtype of Endometrial carcinoma (EC) is linked to a favourable prognosis in the molecular classification. We proposed to ascertain the potential connection between the POLE subtype and improved prognosis. In order to forecast the prognosis, least absolute shrinkage and selection operator (LASSO) Cox regression analysis and weighted gene co-expression network analysis (WGCNA) were employed, and a POLE-related risk signature (PRS) model was developed and validated. Single-sample gene set enrichment analysis (ssGSEA) with the "GSVA" package was employed to analyse immunity characteristics. Drug susceptibility studies were conducted to compare the half-maximal inhibitory concentration (IC₅₀) of medicines between high- and low-risk groups. The PRS model was ge

SUBMITTER: Qiu W 

PROVIDER: S-EPMC11040042 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature