Maternal immune activation induces sex-dependent behavioral differences in a rat model of schizophrenia.

ABSTRACT:

Background

Maternal immune activation (MIA) is a mature means to construct a schizophrenia model. However, some preclinical studies have reported that a MIA-induced schizophrenia model seemed to have gender heterogeneity in behavioral phenotype. On the other hand, the MIA's paradigms were diverse in different studies, and many details could affect the effect of MIA. To some extent, it is not credible and scientific to directly compare the gender differences of different MIA programs. Therefore, it is necessary to study whether the sex of the exposed offspring leads to behavioral differences on the premise of maintaining a consistent MIA mode.

Methods

An animal model of schizophrenia was established by the administration of 10 mg/kg Poly (I: C) when dams were on day 9 of gest

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11040086 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature