The functions of exosomes targeting astrocytes and astrocyte-derived exosomes targeting other cell types.

ABSTRACT: Astrocytes are the most abundant glial cells in the central nervous system; they participate in crucial biological processes, maintain brain structure, and regulate nervous system function. Exosomes are cell-derived extracellular vesicles containing various bioactive molecules including proteins, peptides, nucleotides, and lipids secreted from their cellular sources. Increasing evidence shows that exosomes participate in a communication network in the nervous system, in which astrocyte-derived exosomes play important roles. In this review, we have summarized the effects of exosomes targeting astrocytes and the astrocyte-derived exosomes targeting other cell types in the central nervous system. We also discuss the potential research directions of the exosome-based communication network in t

SUBMITTER: Xu H 

PROVIDER: S-EPMC11040311 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature