Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties.

ABSTRACT: Underwater adhesives with injectable, organic solvent-free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post-cure reaction of isocyanate esterification without organic solvents. The PUWA is created through the injectable two component curing process of component A (biocompatible polyurethane prepolymer) and component B (dopamine modified lysine derivatives: chain extender-LDA and crosslinker-L₃DA). The two-component adhesive cures quickly and firmly underwater, with an impressive bonding strength of 40 kPa on pork skin and excellent burst pressure of 394 mmHg. Moreover, the PUWA exhibits robust adhesion strength in host

SUBMITTER: Guo X 

PROVIDER: S-EPMC11040379 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature