Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants.

ABSTRACT: Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. There are varying clinical presentations of progressive supranuclear palsy with different neuroimaging signatures, presumed to be due to different topographical distributions and burden of tau. The classic Richardson syndrome presentation is considered a subcortical variant, whilst progressive supranuclear palsy with predominant speech and language impairment is considered a cortical variant, although the pathological underpinnings of these variants are unclear. In this case-control study, we aimed to determine whether patterns of regional tau pathology differed between these vari

SUBMITTER: Orlandi F 

PROVIDER: S-EPMC11040515 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature