Aminothiazolone Inhibitors Disrupt the Protein-RNA Interaction of METTL16 and Modulate the m⁶A RNA Modification.

ABSTRACT: Targeting RNA-binding and modifying proteins via small molecules to modulate post-transcriptional modifications have emerged as a new frontier for chemical biology and therapeutic research. One such RNA-binding protein that regulates the most prevalent eukaryotic RNA modification, N⁶-methyladenosine (m⁶A), is the methyltransferase-like protein 16 (METTL16), which plays an oncogenic role in cancers by cofunctioning with other nucleic acid-binding proteins. To date, no potent small-molecule inhibitor of METTL16 or modulator interfering with the METTL16-RNA interaction has been reported and validated, highlighting the unmet need to develop such small molecules to investigate the METTL16-involved regulatory network. Herein, we described the identification of a seri

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11040665 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature