Construction and validation of a nomogram for predicting overall survival of patients with stage III/IV early-onset colorectal cancer.

ABSTRACT:

Purpose

This study aimed to identify prognostic factors and develop a nomogram for predicting overall survival (OS) in stage III/IV early-onset colorectal cancer (EO-CRC).

Methods

Stage III/IV EO-CRC patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015. The datasets were randomly divided (2:1) into training and validation sets. A nomogram predicting OS was developed based on the prognostic factors identified by Cox regression analysis in the training cohort. Moreover, the predictive performance of the nomogram was assessed using the receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Subsequently, the internal validation was performed using the validation cohort.

SUBMITTER: Yin W 

PROVIDER: S-EPMC11040690 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature