Studies towards the Enantioselective Synthesis of Cryptowolinol via Pd⁰-Catalyzed C(sp³)-H Arylation/Parallel Kinetic Resolution.

ABSTRACT: We report a model study towards the enantioselective synthesis of the dibenzopyrrocoline alkaloid (-)-cryptowolinol. The key step involves a challenging enantioselective Pd⁰-catalyzed C(sp³)-H arylation performed with a chiral NHC ligand, which proceeds via parallel kinetic resolution (PKR). A very efficient PKR process was achieved on a deoxygenated model substrate and was successfully transposed to a potential intermediate en route to (-)-cryptowolinol.

SUBMITTER: Miyakoshi T 

PROVIDER: S-EPMC11040710 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature