Analysis and prediction of interactions between transmembrane and non-transmembrane proteins.

ABSTRACT:

Background

Most of the important biological mechanisms and functions of transmembrane proteins (TMPs) are realized through their interactions with non-transmembrane proteins(nonTMPs). The interactions between TMPs and nonTMPs in cells play vital roles in intracellular signaling, energy metabolism, investigating membrane-crossing mechanisms, correlations between disease and drugs.

Results

Despite the importance of TMP-nonTMP interactions, the study of them remains in the wet experimental stage, lacking specific and comprehensive studies in the field of bioinformatics. To fill this gap, we performed a comprehensive statistical analysis of known TMP-nonTMP interactions and constructed a deep learning-based predictor to identify potential interactions. The statistical analysis d

SUBMITTER: Lu C 

PROVIDER: S-EPMC11040819 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature