Blood cell parameters and risk of nonalcoholic fatty liver disease: a comprehensive Mendelian randomization study.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is on the rise globally, and past research suggests a significant association with various blood cell components. Our goal is to explore the potential correlation between whole blood cell indices and NAFLD risk using Mendelian randomization (MR).

Methods

We analyzed data from 4,198 participants in the 2017-2018 National Health and Nutrition Examination Survey to investigate the link between blood cell indicators and NAFLD. Using various methods like weighted quantile sum and multivariate logistic regression, we assessed the association. Additionally, two-sample Mendelian randomization were employed to infer causality for 36 blood cell indicators and NAFLD.

Results

Multivariate logistic regression identified 10 NAFLD

SUBMITTER: Zhu N 

PROVIDER: S-EPMC11040836 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature