Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Previous studies have reported associations between obstructive sleep apnea (OSA) and several mental disorders. However, further research is required to determine whether these associations are causal. Therefore, we evaluated the bidirectional causality between the genetic liability for OSA and nine mental disorders by using Mendelian randomization (MR).

Method

We performed two-sample bidirectional MR of genetic variants for OSA and nine mental disorders. Summary statistics on OSA and the nine mental disorders were extracted from the FinnGen study and the Psychiatric Genomics Consortium. The primary analytical approach for estimating causal effects was the inverse-variance weighted (IVW), with the weighted median and MR Egger as complementary methods. The MR Egger

SUBMITTER: Liu H 

PROVIDER: S-EPMC11040841 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature