C6orf15 promotes liver metastasis via WNT/β-catenin signalling in colorectal cancer.

ABSTRACT:

Background

Colon cancer ranks third among global tumours and second in cancer-related mortality, prompting an urgent need to explore new therapeutic targets. C6orf15 is a novel gene that has been reported only in Sjogren's syndrome and systemic lupus erythematosus patients. We found a close correlation between increased C6orf15 expression and the occurrence of colon cancer. The aim of this study was to explore the potential of C6orf15 as a therapeutic target for colorectal cancer.

Method

RNA-seq differential expression analysis of the TCGA database was performed using the R package 'limma.' The correlation between target genes and survival as well as tumour analysis was analysed using GEPIA. Western blot and PCR were used to assess C6orf15 expression in colorectal cancer tis

SUBMITTER: Yu J 

PROVIDER: S-EPMC11040941 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature