Prognostic analysis of hepatocellular carcinoma based on cuproptosis -associated lncRNAs.

ABSTRACT:

Objectives

Cuproptosis represents an innovative type of cell death, distinct from apoptosis, driven by copper dependency, yet the involvement of copper apoptosis-associated long non-coding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) remains unclear. This study is dedicated to unveiling the role and significance of these copper apoptosis-related lncRNAs within the context of HCC, focusing on their impact on both the development of the disease and its prognosis.

Methods

We conducted an analysis of gene transcriptomic and clinical data for HCC cases by sourcing information from The Cancer Genome Atlas database. By incorporating cuproptosis-related genes, we established prognostic features associated with cuproptosis-related lncRNAs. Furthermore, we elucidated the mechani

SUBMITTER: Wei M 

PROVIDER: S-EPMC11040954 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature