Meta-analysis of the human upper respiratory tract microbiome reveals robust taxonomic associations with health and disease.

ABSTRACT:

Background

The human upper respiratory tract (URT) microbiome, like the gut microbiome, varies across individuals and between health and disease states. However, study-to-study heterogeneity in reported case-control results has made the identification of consistent and generalizable URT-disease associations difficult.

Results

In order to address this issue, we assembled 26 independent 16S rRNA gene amplicon sequencing data sets from case-control URT studies, with approximately 2-3 studies per respiratory condition and ten distinct conditions covering common chronic and acute respiratory diseases. We leveraged the healthy control data across studies to investigate URT associations with age, sex, and geographic location, in order to isolate these associations from health and d

SUBMITTER: Quinn-Bohmann N 

PROVIDER: S-EPMC11040984 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature