Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression.

ABSTRACT:

Background

Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has attracted more and more attention. The aim of this study was to evaluate the link between iodothyronine deiodinase 3 promoter region fragment FA27 (DIO3-FA27) methylation levels, biochemical indices, and HF.

Results

The methylation levels of DIO3-FA27_CpG_11.12 and DIO3-FA27_CpG_23.24 significantly differed in HF patients with different degrees. Multivariate logistic regression analysis indicated that the relative HF risk in the third and fourth quartiles of activated partial thromboplastin time and fibrin degradation products. The results of the restricted

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11040988 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature