Exertional heat stroke-induced changes in gut microbiota cause cognitive impairment in mice.

ABSTRACT:

Background

The incidence of exertional heat stroke (EHS) escalates during periods of elevated temperatures, potentially leading to persistent cognitive impairment postrecovery. Currently, effective prophylactic or therapeutic measures against EHS are nonexistent.

Methods

The selection of days 14 and 23 postinduction for detailed examination was guided by TEM of neuronal cells and HE staining of intestinal villi and the hippocampal regions. Fecal specimens from the ileum and cecum at these designated times were analyzed for changes in gut microbiota and metabolic products. Bioinformatic analyses facilitated the identification of pivotal microbial species and metabolites. The influence of supplementing these identified microorganisms on behavioral outcomes and the expression o

SUBMITTER: Xie J 

PROVIDER: S-EPMC11040997 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature