Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD.

ABSTRACT:

Background

Exposure to noxious particles, including cigarette smoke and fine particulate matter (PM_2.5), is a risk factor for chronic obstructive pulmonary disease (COPD) and promotes inflammation and cell death in the lungs. We investigated the combined effects of cigarette smoking and PM_2.5 exposure in patients with COPD, mice, and human bronchial epithelial cells.

Methods

The relationship between PM_2.5 exposure and clinical parameters was investigated in patients with COPD based on smoking status. Alveolar destruction, inflammatory cell infiltration, and pro-inflammatory cytokines were monitored in the smoking-exposed emphysema mouse model. To investigate the mechanisms, cell viability and death and pyroptosis-related changes in BEAS-2B ce

SUBMITTER: Chung C 

PROVIDER: S-EPMC11041029 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature