Optimal allocation strategies in platform trials with continuous endpoints.

ABSTRACT: Platform trials are randomized clinical trials that allow simultaneous comparison of multiple interventions, usually against a common control. Arms to test experimental interventions may enter and leave the platform over time. This implies that the number of experimental intervention arms in the trial may change as the trial progresses. Determining optimal allocation rates to allocate patients to the treatment and control arms in platform trials is challenging because the optimal allocation depends on the number of arms in the platform and the latter typically varies over time. In addition, the optimal allocation depends on the analysis strategy used and the optimality criteria considered. In this article, we derive optimal treatment allocation rates for platform trials with shared control

SUBMITTER: Bofill Roig M 

PROVIDER: S-EPMC11041082 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature