Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential.

ABSTRACT: Background: Prostate cancer and non-small cell lung cancer (NSCLC) present significant challenges in the development of effective therapeutic strategies. Hormone therapies for prostate cancer target androgen receptors and prostate-specific antigen markers. However, treatment options for prostatic small-cell neuroendocrine carcinoma are limited. NSCLC, on the other hand, is primarily treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors but exhibits resistance. This study explored a novel therapeutic approach by investigating the potential anticancer properties of vitekwangin B, a natural compound derived from Vitex trifolia. Methods: Vitekwangin B was chromatographically isolated from the fruits of V. trifolia. ANO1 protein levels in pr

SUBMITTER: Seo Y 

PROVIDER: S-EPMC11041392 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature