A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.

ABSTRACT: Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary thermoceptive neurons in the pontine parabrachial nucleus becoming well characterized¹. Tanycytes are a specialized cell type along the wall of the third ventricle² that bidirectionally transport hormones and signalling molecules between the brain's parenchyma and ventricular system^3-8. Here we show that tanycytes are activated upon acute thermal challenge and are necessary to reduce food intake afterwards. Virus-mediated gene manipulation and circuit mapping showed that thermosensing glutamatergic neurons of the par

SUBMITTER: Benevento M 

PROVIDER: S-EPMC11041654 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature