A comparison of visual assessment and semi-quantification for the diagnostic and prognostic use of [¹⁸F]flortaucipir PET in a memory clinic cohort.

ABSTRACT:

Purpose

[¹⁸F]Flortaucipir PET is a powerful diagnostic and prognostic tool for Alzheimer's disease (AD). Tau status definition is mainly based in the literature on semi-quantitative measures while in clinical settings visual assessment is usually preferred. We compared visual assessment with established semi-quantitative measures to classify subjects and predict the risk of cognitive decline in a memory clinic population.

Methods

We included 245 individuals from the Geneva Memory Clinic who underwent [¹⁸F]flortaucipir PET. Amyloid status was available for 207 individuals and clinical follow-up for 135. All scans were blindly evaluated by three independent raters who visually classified the scans according to Braak stages. Standardized uptake value ratio

SUBMITTER: Mathoux G 

PROVIDER: S-EPMC11041710 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature