Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease.

ABSTRACT:

Background

Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationship between these and patient outcome.

Methods

We studied 1926 unrelated patients with advanced CRC from COIN and COIN-B. Of 205 CRC-risk SNPs, 19 were directly genotyped and 162 were imputed, and of 53 risk genes, 52 were tested. An additive Cox model for overall survival was adjusted for known prognostic factors. For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of P = 2.1 × 10^-4. We examined SNPs as expression quantitative trait loci (eQTL) and the relationship between gene expres

SUBMITTER: Wills C 

PROVIDER: S-EPMC11041780 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature