Synthesis and biological evaluation of new naphthalimide-thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>.

ABSTRACT: The emergence of antibiotic resistance to S. aureus and M. tuberculosis, particularly MRSA, VRSA, and drug-resistant tuberculosis, poses a serious threat to human health. Towards discovering new antibacterial agents, we designed and synthesized a series of new naphthalimide-thiourea derivatives and evaluated them against a panel of bacterial strains consisting of E. coli, S. aureus, K. pneumoniae, P. aeruginosa, A. baumannii and various mycobacterial pathogens. Compounds 4a, 4l, 4m, 4n, 4q, 9f, 9l, 13a, 13d, 13e, 17a, 17b, 17c, 17d, and 17e demonstrated potent antibacterial activity against S. aureus with MIC 0.03-8 μg mL^-1. In addition, these compounds have also exhibited potent inhibition against MDR strains of S. aure

SUBMITTER: Rana P 

PROVIDER: S-EPMC11042119 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature