T follicular helper cell profiles differ by malaria antigen and for children compared to adults.

ABSTRACT:

Background

Circulating T-follicular helper (cT_FH) cells have the potential to provide an additional correlate of protection against Plasmodium falciparum (Pf) as they are essential to promote B-cell production of long-lasting antibodies. Assessing the specificity of cT_FH subsets to individual malaria antigens is vital to understanding the variation observed in antibody responses and identifying promising malaria vaccine candidates.

Methods

Using spectral flow cytometry and unbiased clustering analysis, we assessed antigen-specific cT_FH cell recall responses in vitro to malaria vaccine candidates Pf-schizont egress antigen-1 (PfSEA-1A) and Pf-glutamic acid-rich protein (PfGARP) within a cross-se

SUBMITTER: Forconi CS 

PROVIDER: S-EPMC11042194 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature