Biophysical characterization of high-confidence, small human proteins.

ABSTRACT: Significant efforts have been made to characterize the biophysical properties of proteins. Small proteins have received less attention because their annotation has historically been less reliable. However, recent improvements in sequencing, proteomics, and bioinformatics techniques have led to the high-confidence annotation of small open reading frames (smORFs) that encode for functional proteins, producing smORF-encoded proteins (SEPs). SEPs have been found to perform critical functions in several species, including humans. While significant efforts have been made to annotate SEPs, less attention has been given to the biophysical properties of these proteins. We characterized the distributions of predicted and curated biophysical properties, including sequence composition, structure, loca

SUBMITTER: Whited AM 

PROVIDER: S-EPMC11042228 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature