Female GluA3-KO mice show early onset hearing loss and afferent swellings in ambient sound levels.

ABSTRACT: AMPA-type glutamate receptors (AMPAR) mediate excitatory cochlear transmission. However, the unique roles of AMPAR subunits are unresolved. Lack of subunit GluA3 (Gria3^KO) in male mice reduced cochlear output by 8-weeks of age. Since Gria3 is X-linked and considering sex differences in hearing vulnerability, we hypothesized accelerated presbycusis in Gria3^KO females. Here, auditory brainstem responses (ABR) were similar in 3-week-old female Gria3^WT and Gria3^KO mice. However, when raised in ambient sound, ABR thresholds were elevated and wave-1 amplitudes were diminished at 5-weeks and older in Gria3^KO. In contrast, these metrics were similar between genotypes

SUBMITTER: Pal I 

PROVIDER: S-EPMC11042237 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature