Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish.

ABSTRACT: Dysregulation of sleep has widespread health consequences and represents an enormous health burden. Short-sleeping individuals are predisposed to the effects of neurodegeneration, suggesting a critical role for sleep in the maintenance of neuronal health. While the effects of sleep on cellular function are not completely understood, growing evidence has identified an association between sleep loss and DNA damage, raising the possibility that sleep facilitates efficient DNA repair. The Mexican tetra fish, Astyanax mexicanus provides a model to investigate the evolutionary basis for changes in sleep and the consequences of sleep loss. Multiple cave-adapted populations of these fish have evolved to sleep for substantially less time compared to surface populations of the same species wi

SUBMITTER: Lloyd E 

PROVIDER: S-EPMC11042282 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature