Whole-genome duplication in the Multicellularity Long Term Evolution Experiment.

ABSTRACT: Whole-genome duplication (WGD) is widespread across eukaryotes and can promote adaptive evolution^1-4. However, given the instability of newly-formed polyploid genomes^5-7, understanding how WGDs arise in a population, persist, and underpin adaptations remains a challenge. Using our ongoing Multicellularity Long Term Evolution Experiment (MuLTEE)⁸, we show that diploid snowflake yeast (Saccharomyces cerevisiae) under selection for larger multicellular size rapidly undergo spontaneous WGD. From its origin within the first 50 days of the experiment, tetraploids persist for the next 950 days (nearly 5,000 generations, the current leading edge of our experiment) in ten replicate populations, despite being genomically unstable. Using synthetic reconstructio

SUBMITTER: Tong K 

PROVIDER: S-EPMC11042302 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature