Genetic Factors Associated With Adverse Pregnancy Outcomes in Chronic Pancreatitis.

ABSTRACT:

Introduction

The effects of genetic factors on pregnancy outcomes in chronic pancreatitis (CP) patients remain unclear. We evaluated the impacts of clinical features and mutations in main CP-susceptibility genes ( SPINK1 , PRSS1 , CTRC , and CFTR ) on pregnancy outcomes in Chinese CP patients.

Methods

This was a prospective cohort study with 14-year follow-up. The sample comprised female CP patients with documented pregnancy and known genetic backgrounds. Adverse pregnancy outcomes were compared between patients with and without gene mutations. Univariate and multivariate analyses were performed to determine the impact factors for adverse pregnancy outcomes.

Results

Totally, 160 female CP patients with a pregnancy history were enrolled; 59.4% of patients carried patho

SUBMITTER: Wu D 

PROVIDER: S-EPMC11042769 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature