Potential value of expression of receptor accessory protein 4 for evaluating the prognosis of lower-grade glioma patients.

ABSTRACT:

Background

REEP4 is involved in the regulation of the biological process of mitosis. Lower grade glioma (LGG), as a malignant tumor, is accompanied by abnormalities in mitosis, but there have been no reports of REEP4 so far.

Methods

We collected transcriptome data, DNA methylation data and the clinical characteristics of thousands of patients with LGG. Various big data analysis methods and molecular biology experiments were employed to reveal the impact of REEP4 on the pathological process of LGG.

Results

It was found that the expression of REEP4 was significantly elevated and negatively regulated by its methylation site. Therefore, both the high expression of REEP4 and low methylation state of cg16311504 showed that the patients are correlated with lower patient surv

SUBMITTER: Luo S 

PROVIDER: S-EPMC11042925 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature