Preliminary study on the dynamic positron emission tomography imaging with ¹¹C-ER176 to delineate macrophage activation in diabetic gastroparesis.

ABSTRACT:

Background

Animal models and human data have suggested macrophage-driven immune dysregulation in diabetic gastroparesis (DG). Translocator protein (TSPO) upregulation has been suggested to indicate activated state of macrophages and ER176 is a high affinity third generation TSPO-specific radioligand. The aim of this study was to determine feasibility of dynamic ¹¹C-ER 176 PET to identify macrophage activation in DG.

Methods

Twelve patients, all females, were recruited (4 DG, 4 diabetics, and 4 healthy volunteers) for ¹¹C-ER 176 PET/CT scanning. The standardized uptake value (SUV_max) in the gastric fundus, body, pylorus, and descending part of the duodenum were compared between three groups using Kruskal-Wallis test to perform the comparisons,

SUBMITTER: Maalouf E 

PROVIDER: S-EPMC11042975 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature