Brachytherapy at the nanoscale with protein functionalized and intrinsically radiolabeled [¹⁶⁹Yb]Yb₂O₃ nanoseeds.

ABSTRACT:

Purpose

Classical brachytherapy of solid malignant tumors is an invasive procedure which often results in an uneven dose distribution, while requiring surgical removal of sealed radioactive seed sources after a certain period of time. To circumvent these issues, we report the synthesis of intrinsically radiolabeled and gum Arabic glycoprotein functionalized [¹⁶⁹Yb]Yb₂O₃ nanoseeds as a novel nanoscale brachytherapy agent, which could directly be administered via intratumoral injection for tumor therapy.

Methods

¹⁶⁹Yb (T_½ = 32 days) was produced by neutron irradiation of enriched (15.2% in ¹⁶⁸Yb) Yb₂O₃ target in a nuclear reactor, radiochemically converted to [¹⁶⁹Yb]YbCl₃

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC11042995 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature