Evaluation of Plasma Biomarkers for Causal Association With Peripheral Artery Disease.

ABSTRACT:

Background

Hundreds of biomarkers for peripheral artery disease (PAD) have been reported in the literature; however, the observational nature of these studies limits causal inference due to the potential of reverse causality and residual confounding. We sought to evaluate the potential causal impact of putative PAD biomarkers identified in human observational studies through genetic causal inference methods.

Methods

Putative circulating PAD biomarkers were identified from human observational studies through a comprehensive literature search based on terms related to PAD using PubMed, Cochrane, and Embase. Genetic instruments were generated from publicly available genome-wide association studies of circulating biomarkers. Two-sample Mendelian randomization was used to test th

SUBMITTER: Sharma P 

PROVIDER: S-EPMC11043009 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature