[⁶⁸ Ga]Ga-FAPI-46 PET/CT for locoregional lymph node staging in urothelial carcinoma of the bladder prior to cystectomy: initial experiences from a pilot analysis.

ABSTRACT:

Introduction

[⁶⁸ Ga]Ga-FAPI-46 PET/CT is a novel hybrid imaging method that previously showed additional diagnostic value in the assessment of distant urothelial carcinoma lesions. We hypothesized that patients with bladder cancer benefit from [⁶⁸ Ga]Ga-FAPI-46 PET/CT prior to radical cystectomy for locoregional lymph node staging.

Materials and methods

Eighteen patients underwent [⁶⁸ Ga]Ga-FAPI-46 PET/CT for evaluation of lymph node (LN) status in predefined LN regions. Two hundred twenty-nine intraoperatively removed LN served as histopathological reference standard.

Results

Urothelial carcinoma (UC) spread was found in ten LN in seven different regions (14.3%). Hereby, [⁶⁸ Ga]Ga-FAPI-46 PET/CT was positive in four out of

SUBMITTER: Unterrainer LM 

PROVIDER: S-EPMC11043110 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature