The accuracy and intra- and interobserver variability of PSMA PET/CT for the local staging of primary prostate cancer.

ABSTRACT:

Purpose

Prostate-specific membrane antigen (PSMA) positron emission tomography/ computed tomography (PET/CT) is recognized as the most accurate imaging modality for detection of metastatic high-risk prostate cancer (PCa). Its role in the local staging of disease is yet unclear. We assessed the intra- and interobserver variability, as well as the diagnostic accuracy of the PSMA PET/CT based molecular imaging local tumour stage (miT-stage) for the local tumour stage assessment in a large, multicentre cohort of patients with intermediate and high-risk primary PCa, with the radical prostatectomy specimen (pT-stage) serving as the reference standard.

Methods

A total of 600 patients who underwent staging PSMA PET/CT before robot-assisted radical prostatectomy was studied. In 579 P

SUBMITTER: Donswijk ML 

PROVIDER: S-EPMC11043118 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature