Template-Based Modelling of the Structure of Fungal Effector Proteins.

ABSTRACT: The discovery of new fungal effector proteins is necessary to enable the screening of cultivars for disease resistance. Sequence-based bioinformatics methods have been used for this purpose, but only a limited number of functional effector proteins have been successfully predicted and subsequently validated experimentally. A significant obstacle is that many fungal effector proteins discovered so far lack sequence similarity or conserved sequence motifs. The availability of experimentally determined three-dimensional (3D) structures of a number of effector proteins has recently highlighted structural similarities amongst groups of sequence-dissimilar fungal effectors, enabling the search for similar structural folds amongst effector sequence candidates. We have applied template-based model

SUBMITTER: Rozano L 

PROVIDER: S-EPMC11043172 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature