Carboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation.

ABSTRACT:

Background

The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired gas exchange. In most centers oxygenator performance is monitored only on a once daily basis. Carboxyhemoglobin (COHb) is generated upon red cell lysis and is routinely measured with any co-oximetry performed to surveille gas exchange and acid-base homeostasis every couple of hours. This retrospective cohort study aims to evaluate COHb in the arterial blood gas as a novel marker of oxygenator dysfunction and its predictive value for imminent oxygenator change.

Results

Out of the 484 screened patients on ECMO 89, cumulatively requiring 116 oxygenator changes w

SUBMITTER: Erlebach R 

PROVIDER: S-EPMC11043307 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature