A high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL-LDLR axis.

ABSTRACT: Most metastases in breast cancer occur via the dissemination of tumor cells through the bloodstream. How tumor cells enter the blood (intravasation) is, however, a poorly understood mechanism at the cellular and molecular levels. Particularly uncharacterized is how intravasation is affected by systemic nutrients. High levels of systemic LDL-cholesterol have been shown to contribute to breast cancer progression and metastasis in various models, but the cellular and molecular mechanisms involved are still undisclosed. Here we show that a high- cholesterol diet promotes intravasation in two mouse models of breast cancer and that this could be reverted by blocking LDL binding to LDLR in tumor cells. Moreover, we show that LDL promotes vascular invasion in vitro and the intercalation of tumor c

SUBMITTER: Magalhaes A 

PROVIDER: S-EPMC11043359 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature