Progression of herpesvirus infection remodels mitochondrial organization and metabolism.

ABSTRACT: Viruses target mitochondria to promote their replication, and infection-induced stress during the progression of infection leads to the regulation of antiviral defenses and mitochondrial metabolism which are opposed by counteracting viral factors. The precise structural and functional changes that underlie how mitochondria react to the infection remain largely unclear. Here we show extensive transcriptional remodeling of protein-encoding host genes involved in the respiratory chain, apoptosis, and structural organization of mitochondria as herpes simplex virus type 1 lytic infection proceeds from early to late stages of infection. High-resolution microscopy and interaction analyses unveiled infection-induced emergence of rough, thin, and elongated mitochondria relocalized to the perinuclea

SUBMITTER: Leclerc S 

PROVIDER: S-EPMC11045090 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature