KIS counteracts PTBP2 and regulates alternative exon usage in neurons.

ABSTRACT: Alternative RNA splicing is an essential and dynamic process in neuronal differentiation and synapse maturation, and dysregulation of this process has been associated with neurodegenerative diseases. Recent studies have revealed the importance of RNA-binding proteins in the regulation of neuronal splicing programs. However, the molecular mechanisms involved in the control of these splicing regulators are still unclear. Here, we show that KIS, a kinase upregulated in the developmental brain, imposes a genome-wide alteration in exon usage during neuronal differentiation in mice. KIS contains a protein-recognition domain common to spliceosomal components and phosphorylates PTBP2, counteracting the role of this splicing factor in exon exclusion. At the molecular level, phosphorylation of unstr

SUBMITTER: Moreno-Aguilera M 

PROVIDER: S-EPMC11045219 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature