CD4⁺ and CD8⁺ T cells reduce inflammation and promote bone healing in response to titanium implants.

ABSTRACT: T cells are adaptive immune cells essential in pathogenic response, cancer, and autoimmune disorders. During the integration of biomaterials with host tissue, T cells modify the local inflammatory environment by releasing cytokines that promote inflammatory resolution following implantation. T cells are vital for the modulation of innate immune cells, recruitment and proliferation of mesenchymal stem cells (MSCs), and formation of functional tissue around the biomaterial implant. We have demonstrated that deficiency of αβ T cells promotes macrophage polarization towards a pro-inflammatory phenotype and attenuates MSC recruitment and proliferation in vitro and in vivo. The goal of this study was to understand how CD4⁺ and CD8⁺ T cells, subsets of the αβ T cell family,

SUBMITTER: Avery D 

PROVIDER: S-EPMC11045310 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature