Gray matter and episodic memory associations with olfaction in middle-aged to older adults.

ABSTRACT:

Background

Age-related declines in olfaction contribute to low quality of life and appear to occur with declines in cognitive function, including diminished episodic memory. We tested the hypothesis that low gray matter volume within cortical regions that support olfaction and episodic memory can explain age-related differences in olfactory and episodic memory functions.

Methods

T1-weighted images, Sniffin' Sticks olfactory measures, and the NIH Toolbox-Cognition Battery were administered to 131 middle-aged to older adults (50-86 years; 66% female). Correlation was used to examine the associations between these measures. A network-based image processing approach was then used to examine the degree to which spatial patterns of gray matter variance were related to the olfactor

SUBMITTER: Eckert MA 

PROVIDER: S-EPMC11045322 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature