MiR-17-92a-1 cluster host gene: a key regulator in colorectal cancer development and progression.

ABSTRACT: Colorectal cancer (CRC), recognized among the five most prevalent malignancies and most deadly cancers, manifests multifactorial influences stemming from environmental exposures, dietary patterns, age, and genetic predisposition. Although substantial progress has been made in comprehending the etiology of CRC, the precise genetic components driving its pathogenesis remain incompletely elucidated. Within the expansive repertoire of non-coding RNAs, particular focus has centered on the miR-17-92a-1 cluster host gene (MIR17HG) and its associated miRNAs, which actively participate in diverse cellular processes and frequently exhibit heightened expression in various solid tumors, notably CRC. Therefore, the primary objective of this research is to undertake an extensive inquiry into the regulat

SUBMITTER: Mohajeri Khorasani A 

PROVIDER: S-EPMC11045601 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature