Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI.

ABSTRACT:

Objective

To determine the feasibility and biologic correlations of dynamic susceptibility contrast (DSC), dynamic contrast enhanced (DCE), and quantitative maps derived from contrast leakage effects obtained simultaneously in gliomas using dynamic spin-and-gradient-echo echoplanar imaging (dynamic SAGE-EPI) during a single contrast injection.

Materials and methods

Thirty-eight patients with enhancing brain gliomas were prospectively imaged with dynamic SAGE-EPI, which was processed to compute traditional DSC metrics (normalized relative cerebral blood flow [nrCBV], percentage of signal recovery [PSR]), DCE metrics (volume transfer constant [K^trans], extravascular compartment [v_e]), and leakage effect metrics: ΔR_2,ss* (reflecting T₂

SUBMITTER: Sanvito F 

PROVIDER: S-EPMC11045669 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature